Hilton Prague is my go-to hotel in that city

The pavements & cobbles made my trip a nightmare, too difficult for independent mobility . So I’m avoiding Prague for a few years.

Some large shopping malls have splendid accessible toilets.

 Prague is lovely, but I visited before I had mobility issues, but I’m sure it can be done.

 It’s very cobbly!!!!

I had great luck with hotels, but don't remember the name :( we "walked" (i'm a full time wheelchair user t1 complete) everywhere. Cobblestones were a lot of places, especially right downtown, but doable. IF you have a freewheel that would help!

Sadly there is not much accessible nightclubs or nigh public transport. There are accessible taxis which operate by nights. Czech Republic has really bad situation in terms of accessibility in general. 

 I loved it but yeah the sidewalks are cobble. I brought a small ramp with me and it made it way better to get in restaurants and so forth. Prague Castle was accessible. I stayed at Pension Dientzenhofer
Nosticova 465/2, 118 00 Malá Strana, Czechia
+420 257 311 319
https://goo.gl/maps/uKwa6yWBmuUaiAYN9

I’ve requested an accessible room at Park Inn Prague. I’ll be staying there in August.

Prague visitors stay in our 210 modern and fully equipped guest rooms as well as accessible rooms. All guest rooms feature individual climate control, full HD LED smart televisions and spacious bathrooms with walk-in showers or bathtubs. Our grand Superior Rooms with terrace are located on the top floor and feature private terraces with outside seating. The hotel is a non-smoking property and provides rooms suitable for families with children. Access to the rooftop fitness centre is complimentary for all guests.

I've stayed in Hotel Carol last year. Lovely place